| 发明名称 |
RENIN INHIBITORS |
| 摘要 |
Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
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| 申请公布号 |
US2010179109(A1) |
申请公布日期 |
2010.07.15 |
| 申请号 |
US20080450631 |
申请日期 |
2008.04.04 |
| 申请人 |
BALDWIN JONH J;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W;FLAHERTY PATRICK T;GHAVIMI-ALAGHA BAHMAN;GHIRLANDA DAMIANO;ISHCHENKO ALEXEY V;KALLANDER LARA S;LAWHORN BRIAN;LEACH COLIN A;LU QING;MCGEEHAN GERARD;PATTERSON JACLYN R;SIMPSON ROBERT D;SINGH SURESH B;STOY PATRICK;TERRELL LAMONT R;TICE COLIN;XU ZHENRONG;YUAN JING;YUAN CATHERINE C K;ZHANG JING;ZHAO WEI |
发明人 |
BALDWIN JONH J.;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W.;FLAHERTY PATRICK T.;GHAVIMI-ALAGHA BAHMAN;GHIRLANDA DAMIANO;ISHCHENKO ALEXEY V.;KALLANDER LARA S.;LAWHORN BRIAN;LEACH COLIN A.;LU QING;MCGEEHAN GERARD;PATTERSON JACLYN R.;SIMPSON ROBERT D.;SINGH SURESH B.;STOY PATRICK;TERRELL LAMONT R.;TICE COLIN;XU ZHENRONG;YUAN JING;YUAN CATHERINE C. K.;ZHANG JING;ZHAO WEI |
| 分类号 |
A61K31/675;A61K31/445;A61K31/47;A61K31/4965;A61K31/517;A61K31/535;A61K31/5375;A61K31/5377;A61K31/5415;A61K31/55;A61K31/551;A61K31/554;A61K31/566;A61P9/10;A61P9/12;A61P25/22;A61P25/28;A61P27/06;A61P31/18;A61P33/06;C07D211/34;C07D265/30;C07D413/06 |
主分类号 |
A61K31/675 |
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