| 摘要 |
The present invention relates to a method of producing an optically active cyanohydrin derivative, which comprises reacting an aldehyde or an asymmetrical ketone with a cyanating agent in the presence of a Lewis base and a titanium compound produced from a partial hydrolysate of titanium tetraalkoxide and an optically active ligand represented by formula (II) or a titanium oxoalkoxide compound represented by formula (I) [TixOy](OR1)4x-2y, and an optically active ligand represented by formula (II), wherein R1 is an optionally substituted alkyl group or an optionally substituted aryl group; x is an integer of not less than 2; y is an integer of not less than 1; and y/x satisfies 0.1<y/x≦̸1.5, wherein R2, R3 and R4 are independently a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aromatic heterocyclic group, an acyl group, an alkoxycarbonyl group or an aryloxycarbonyl group, each of which may be optionally substituent, two or more of R2, R3 and R4 may be linked together to form a ring, and the ring may have a substituent; and A represents a hydrocarbon containing group with three or more carbon atoms having an asymmetric carbon atom or axial asymmetry.
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