发明名称 COMBINATION THERAPY
摘要 <P>PROBLEM TO BE SOLVED: To provide a new human deoxyribonuclease, referred to as human DNase II. <P>SOLUTION: The nucleic acid sequences encoding the human DNase II, thereby enabling the production of the human DNase II is obtained by a recombinant DNA method in a quantity sufficient for clinical use. The human DNase II has an acid pH optimum properties as characteristics of a DNase II protein, and does not require a divalent cation for activation. The diagnostic and therapeutic uses of the human DNase II, and the pharmaceutical compositions are also provided. <P>COPYRIGHT: (C)2010,JPO&INPIT
申请公布号 JP2010154850(A) 申请公布日期 2010.07.15
申请号 JP20090272240 申请日期 2009.11.30
申请人 GENENTECH INC 发明人 BAKER KEVIN P;BARON WILL F
分类号 C12N15/09;A61K31/00;A61K38/00;A61K38/46;A61K39/395;A61P1/00;A61P1/02;A61P1/16;A61P1/18;A61P9/00;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P19/02;A61P31/00;A61P31/10;A61P37/00;A61P37/02;A61P37/06;A61P43/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N9/22;C12P21/08 主分类号 C12N15/09
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