METHOD FOR EVOLUTIONARY DESIGN OF BIOCHEMICAL REACTION NETWORK

摘要

PROBLEM TO BE SOLVED: To provide a method for achieving an optimal function of a biochemical reaction network.

SOLUTION: The methods can be performed in silico using a reconstruction of a biochemical reaction network of a cell and iterative optimization procedures. The methods can further include laboratory culturing steps to confirm and possibly expand the determinations made using the in silico methods, and to produce a cultured cell, or population of cells, with optimal functions. The current invention includes computer systems and computer products including computer-readable program code for performing the in silico steps.

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