发明名称 |
METHOD FOR IDENTIFYING GENES INVOLVED IN TRAIL-INDUCED APOPTOSIS AND THERAPEUTIC APPLICATIONS THEREOF |
摘要 |
The invention relates to methods for identifying genes involved in TRAIL- induced apoptosis, to inhibitors of the expression of genes inducing resistance of cells to TRAIL-induced apoptosis and to activators of the expression of a gene sensitizing cells to TRAIL-induced apoptosis. The invention also relates to methods for sensitizing cells to TRAIL-induced apoptosis, methods for treating hyperproliferative diseases, methods for determining the responsiveness of a subject suffering from a hyperproliferative disease to TRAIL, to pharmaceutical compositions comprising products capable of sensitizing cells to TRAIL-induced apoptosis, and to methods for determining the prognosis of a subject suffering from a hyperproliferative disease.
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申请公布号 |
CA2745775(A1) |
申请公布日期 |
2010.07.15 |
申请号 |
CA20092745775 |
申请日期 |
2009.12.18 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS-;UNIVERSITE DE MONTPELLIER 2 SCIENCES ET TECHNIQUES;UNIVERSITE DE MONTPELLIER 1 |
发明人 |
HAHNE, MICHAEL;COMBE, BERNARD;MOREL, JACQUES;AUDO, RACHEL;KNAPIK, ALICA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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