发明名称 |
REAGENTS FOR INDUCING AN IMMUNE RESPONSE |
摘要 |
<p>The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.</p> |
申请公布号 |
EP2205256(A2) |
申请公布日期 |
2010.07.14 |
申请号 |
EP20080833980 |
申请日期 |
2008.09.26 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;HOWARD HUGHES MEDICAL INSTITUTE |
发明人 |
REINHERZ, ELLIS L.;KIM, MIKYUNG;WAGNER, GERHARD;SUN, ZEHN-YU J.;OH , KYOUNG JOON;IRVINE, DARRELL, J.;BERSHTEYN, ANNA |
分类号 |
A61K38/16;A61K9/16;A61K39/21;A61P31/18;C07K16/10 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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