发明名称 |
NOVEL CHROMATOGRAPHY METHODS |
摘要 |
<p>The present invention relates to novel HPLC methods for the analysis of the API formoterol and related substances. In a first method the mobile phase comprises two or more liquids, and the relative concentration of the liquids is varied to a predetermined gradient. In a second method the mobile phase comprises a first liquid A comprising an aqueous solution of ammonium acetate and a second liquid B comprising a dipolar aprotic solvent. In a third method the mobile phase comprises a first liquid A comprising an aqueous solution of ammonium acetate with a concentration of 0.001 to 0.025M, and a second liquid B. The present invention also relates to a method for analysing a substance, comprising the detection and optional quantification of one or more specific impurities.</p> |
申请公布号 |
EP2205966(A2) |
申请公布日期 |
2010.07.14 |
申请号 |
EP20080806777 |
申请日期 |
2008.10.18 |
申请人 |
GENERICS [UK] LIMITED |
发明人 |
KUMAR, E.K.S. VIJAYA;SAMEL, AMIT;PATIL, SACHIN;DHORE, DILIP |
分类号 |
G01N30/34;G01N33/94 |
主分类号 |
G01N30/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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