ISOQUINOLINE COMPOUNDS AND MEDICINAL USE THEREOF

摘要

An isoquinoline compound represented by the following general formula (1): (1) its optically active isomers, pharmaceutically acceptable salts thereof, water-adducts thereof, hydrates thereof and solvates thereof; a preventive and/or a remedy for a disease caused by the hyperfunction of poly(ADP-ribose) synthase which contains the above compound; and a poly(ADP-ribose) synthase inhibitor which contains the above compound. This compound is also useful as a preventive and/or a remedy for brain infarction, in particular, a preventive and/or a remedy for brain infarction in the acute stage. Moreover, it is useful as a preventive and/or a remedy for improving nerve symptoms accompanying brain infarction, in particular, brain infarction in the acute stage.