| 摘要 |
The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein Ris hydrogen, halo, polyhaloCalkyl, Calkyl, hydroxyCalkyl, Calkyloxy, Ar or Het; p is an integer equal to 1 or 2; Ris Calkyloxy, CalkyloxyCalkyloxy or Calkylthio ; Ris Calkyl, Ar, Het or Het1; Rand Reach independently are hydrogen, Calkyl or benzyl; or Rand Rtogether and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with Calkyl, halo, polyhaloCalkyl, hydroxy, hydroxyCalkyl, Calkyloxy, amino, mono- or di(Calkyl)amino, Calkylt hio, CalkyloxyCalkyl, C6alkylthioCalkyl or pyrimidinyl; Ris hydrogen, halo, polyhaloCalkyl, Calkyl, Calkyloxy, Calkylthio; or two vicinal Rradicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH- ; r is an integer equal to 1 or 2; Ris hydrogen, Calkyl, Ar, Het or Het; provided that the bacterial infection is other than a Mycobacterial infection. |
