SAND FLY SALIVARY PROTEINS AS NOVEL FACTOR XA INHIBITORS AND METHODS OF USE

摘要

It has been surprisingly discovered that a sand fly salivary gland polypeptide, or a nucleic acid sequence encoding the polypeptide, can function as an anticoagulant. The present disclosure provides methods of treatment of disorders associated with abnormal coagulation of the blood utilizing compositions that include the sand fly salivary gland polypeptides of the disclosure.