发明名称 |
MUTANT NUCLEIC ACID RELATED TO CHRONIC MYELOPROLIFERATIVE DISORDER AND METHOD OF EVALUATING CHRONIC MYELOPROLIFERATIVE DISORDER |
摘要 |
A new mutant gene related to the onset of CMPD, particularly, the new mutant gene related to the onset of CMPD in patients who develop CMPD despite of JAK2V617F-negative, and an evaluation method for evaluating CMPD are provided. By detecting the following mutation in a JAK2 gene or an EPOR gene in a biological sample of human origin, the possibility of CMPD is evaluated. (a) a mutation from G at the 2116th position to A in a base sequence of SEQ ID NO: 1, (b) a deletion of a nucleotide residue from the 2121st to 2126th position in a base sequence of SEQ ID NO: 1, (c) a mutation from C at the 1641st position to G in a base sequence of SEQ ID NO: 4.
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申请公布号 |
US2010173299(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20080601738 |
申请日期 |
2008.10.31 |
申请人 |
ARKRAY, INC.;NIPPON MEDICAL SCHOOL FOUNDATION |
发明人 |
YAMAGUCHI HIROKI;INAMI MITSUHARU |
分类号 |
C12Q1/68;C07H21/00;C07K14/00;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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