POLYMORPHISMS IN THE XBP-1 GENE ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE

摘要

The present invention is based, at least in part, on the discovery that certain known and novel SNPs located in the XBP-I genomic region at human chromosome 22q are significantly associated with IBD. Such SNPs are useful for determining the predisposition of a human subject to develop inflammatory bowel disease. Accordingly, the present invention provides methods for detecting at least one SNP in the human XBP-I genomic region, as well as methods to determine the predisposition of a human subject to develop inflammatory bowel disease.