发明名称 |
Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same |
摘要 |
This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
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申请公布号 |
US2010173404(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20070447044 |
申请日期 |
2007.10.24 |
申请人 |
KUMON HIROMI;HUH NAM-HO;SAKAGUCHI MASAKIYO;NASU YASUTOMO;ABARZUA CABEZAS FERNANDO GUILLERMO |
发明人 |
KUMON HIROMI;HUH NAM-HO;SAKAGUCHI MASAKIYO;NASU YASUTOMO;ABARZUA CABEZAS FERNANDO GUILLERMO |
分类号 |
C07K14/435;C07H21/04;C12N15/63 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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