发明名称 |
USE OF TAILORED RECOMBINASES FOR THE TREATMENT OF RETROVIRAL INFECTIONS |
摘要 |
The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus.
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申请公布号 |
US2010172881(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20080522127 |
申请日期 |
2008.01.03 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.;TECHNISCHE UNIVERSITAT DRESDEN |
发明人 |
HAUBER JOACHIM;BUCHHOLZ FRANK;HAUBER ILONA;STEWART FRANCIS A.;SARKAR INDRANI |
分类号 |
A61K35/12;A61K31/7088;A61K38/52;A61P31/12;C07H21/00;C12N5/074;C12N9/90;C12N15/74;C12Q1/68;C40B50/06 |
主分类号 |
A61K35/12 |
代理机构 |
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地址 |
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