发明名称 |
PROCESS FOR THE PREPARATION OF BENZIMIDAZOL THIENYLAMINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL AS SODIUM/PROTON EXCHANGER TYPE 3 INHIBITORS |
摘要 |
The present invention is an improved process for the preparation of a sodium/proton exchange inhibitor of sub-type 3 (NHE-3) useful in the treatment of sleep apnea and other related respiratory disorders. The improved synthesis of the NHE-3 inhibitor, more specifically a benzimidazol thienylamine, utilizes novel reagents and chemical intermediates and thereby results in an improved yield and purity of the final product with less reaction or synthetic steps required
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申请公布号 |
US2010174088(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20090637096 |
申请日期 |
2009.12.14 |
申请人 |
SANOFI-AVENTIS U.S. LLC |
发明人 |
AYERS TIMOTHY ALLEN;CHOY NAKYEN;GILL HARPAL S.;HILLEGASS ANDREA;SHAY, JR. JOHN J.;DERDAU VOLKER |
分类号 |
C07D409/12;C07D235/04;C07D333/04 |
主分类号 |
C07D409/12 |
代理机构 |
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