发明名称 |
USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES |
摘要 |
The present invention relates to the field of medicine, in particular the use of an APL-type peptide, derived from the human 60 kDa heat-shock protein or analogues thereof, for preparing a pharmaceutical composition for treating Crohn's disease, ulcerative colitis and type 1 diabetes mellitus. Said peptide is biodistributed to the gastrointestinal tract and promotes the induction of apoptosis of activated T-cells of the intestinal lamina propria and of the peripheral blood of patients with Crohn's disease. Furthermore this peptide induces apoptosis of mononuclear cells of patients with type 1 diabetes mellitus.
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申请公布号 |
CA2748493(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
CA20092748493 |
申请日期 |
2009.12.29 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
BARBERA BETANCOURT, ARIANA;DOMINGUEZ HORTA, MARIA DEL CARMEN;LORENZO PEREZ, NORAILYS;PADRON PALOMARES, GABRIEL RAMON;FALCON CAMA, VIVIANA;MENENDEZ VALDES, IVON |
分类号 |
A61K38/17;A61P1/04;A61P3/10 |
主分类号 |
A61K38/17 |
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