METHOD OF GENERATING REGULATORY T CELLS USING CORD BLOOD AND ADULT BLOOD CD14+ MONOCYTE CELLS
摘要
A method of inducing stable and functional Tregs from human umbilical cord blood and adult blood without requiring the expansion of pre-existing Tregs. The method utilizes CD14+ monocyte cells present in or isolated from cord blood or adult blood to induce functional Tregs from T cells, and particularly T cells that express CD4+, which may also be obtained from cord blood or adult blood. The developed Tregs are long-lasting and maintain their suppressive functions.
申请公布号
WO2010078183(A2)
申请公布日期
2010.07.08
申请号
WO2009US69374
申请日期
2009.12.23
申请人
LOYOLA UNIVERSITY CHICAGO;IWASHIMA, MAKIO;SEKI, YOICHI;CRUZ, VINCENT