发明名称 |
Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
摘要 |
A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a α2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours (e.g., no more than once about every 24 hours) to a subject having a steady state plasma concentration of the α2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
|
申请公布号 |
US2010172991(A1) |
申请公布日期 |
2010.07.08 |
申请号 |
US20090645772 |
申请日期 |
2009.12.23 |
申请人 |
HORACEK HENRY JOSEPH;HE MIN MICHAEL;KHAYRALLAH MOISE A |
发明人 |
HORACEK HENRY JOSEPH;HE MIN MICHAEL;KHAYRALLAH MOISE A. |
分类号 |
A61K9/14;A61K31/4168;A61P3/04;A61P9/04;A61P9/12;A61P25/02;A61P25/06;A61P25/18;A61P25/30;C07D233/50 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|