METHODS FOR SELECTING AN HIV TREATMENT REGIMEN

摘要

The invention features methods for selecting an HIV treatment regimen for HIV positive subjects. Such regimens include the administration of CD59 inhibitors including ?LY domain 4. CD59 activity is associated with a decreased sensitivity to endogenous and exogenous anti-HIV antibodies. Desirably, administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 activity while avoiding the general toxicity associated with full length ILY.