发明名称 |
METHOD FOR THE SYNTHESIS OF ANTICANCER (POLY)AMINOALKYLAMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN |
摘要 |
The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-containing reactant, whose amine functions are not protected, with &bgr;-chloroacetamido-4′-epipodophyllotoxin in a polar aprotic organic solvent. |
申请公布号 |
EP2203455(A1) |
申请公布日期 |
2010.07.07 |
申请号 |
EP20080838681 |
申请日期 |
2008.09.23 |
申请人 |
PIERRE FABRE MEDICAMENT |
发明人 |
GUMINSKI, YVES;GROUSSEAUD, MARTIAL;IMBERT, THIERRY |
分类号 |
C07D493/04 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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