发明名称 |
CLONING AND RECOMBINANT PRODUCTION OF CRF (CORTICOTROPIN RELEASING FACTOR) RECEPTOR(S) |
摘要 |
In accordance with the present invention there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of 10 nM of CRF occupy 50 % of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
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申请公布号 |
CA2162729(C) |
申请公布日期 |
2010.07.06 |
申请号 |
CA19942162729 |
申请日期 |
1994.05.25 |
申请人 |
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发明人 |
PERRIN, MARILYN H.;CHEN, RUOPING;LEWIS, KATHY A.;VALE, WYLIE W., JR.;DONALDSON, CYNTHIA J. |
分类号 |
C12N15/16;G01N33/53;A61K39/395;C07H21/00;C07K14/72;C07K16/28;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/00;C12Q1/68;C12R1/91;G01N33/566 |
主分类号 |
C12N15/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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