The present invention provides compositions and methods for the alimentary delivery of oligonucleotides in an animal, including a human. Modifications to the oligonucleotide which enhance uptake following alimentary delivery are provided.
申请公布号
CA2286396(C)
申请公布日期
2010.07.06
申请号
CA19982286396
申请日期
1998.04.30
申请人
ISIS PHARMACEUTICALS INC.
发明人
DEAN, NICHOLAS M.;BENNET, C. FRANK;MONIA, BRETT P.;DRAPER, KENNETH;ANDERSON, KEVIN P.;BAKER, BRENDA F.;ECKER, DAVID J.
