发明名称 |
5′-modified bicyclic nucleic acid analogs |
摘要 |
The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
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申请公布号 |
US7750131(B2) |
申请公布日期 |
2010.07.06 |
申请号 |
US20090407643 |
申请日期 |
2009.03.19 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
SETH PUNIT P.;SWAYZE ERIC E.;BHAT BALKRISHEN |
分类号 |
C07H19/00;C07H21/00 |
主分类号 |
C07H19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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