发明名称 |
Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone |
摘要 |
A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
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申请公布号 |
US7749734(B2) |
申请公布日期 |
2010.07.06 |
申请号 |
US20050793277 |
申请日期 |
2005.12.22 |
申请人 |
THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OFOSAKA UNIVERSITY |
发明人 |
KOUICHI MORITA;NABESHIMA TAKESHI;MIYAKE SHINICHI;ONISHI TOSHIYUKI;FUKE ISAO;ISHIKAWA TOYOKAZU;GODA HIDEO;ISHIBASHI MASAHIDE;TAKAHASHI MICHIAKI |
分类号 |
C12N7/01;A61K39/12 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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