NEW PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

摘要

PURPOSE: A method for synthesizing an additive salt of ivabradine and pharmaceutically acceptable acid in a high yield is provided. CONSTITUTION: A method for synthesizing a compound of chemical formula VI having racemic or an optically active form comprises: a step of using a compound of chemical formula VIII to a compound of chemical formula VII having racemic or optically active form and a step of performing reductive amination of organic solvent or mixture of the organic solvent under the presence of a reductant.