NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN G PROTEIN-COUPLED RECEPTOR

摘要

PROBLEM TO BE SOLVED: To provide a receptor activated by constitutive receptor activation by a means independent of a ligand and stabilizable in the activated state by a compound such as an endogenous ligand and a drug.

SOLUTION: There are provided a cDNA encoding a non-endogenous, constitutively activatable variant human G protein-coupled receptor (GPCR) containing various human orphan receptors such as hARE-3 (F313K), a vector, the GPCR protein, and a host cell containing the cDNA, etc.

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