According to one aspect there is provided An isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR but has no effect on TSHR constitutive activity wherein the isolated human antibody molecule has the characteristic of patient serum TSHR autoantibodies of inhibiting TSH and M22 binding to the TSHR.
申请公布号
WO2010073012(A2)
申请公布日期
2010.07.01
申请号
WO2009GB02946
申请日期
2009.12.23
申请人
R S R LIMITED;REES SMITH, BERNARD;SANDERS, JANE;FURMANIAK, JADWIGA