发明名称 |
PROCESS FOR PREPARATION OF ESOMEPRAZOLE SODIUM OF HIGH CHEMICAL PURITY AND NEW FORMS OF ESOMEPRAZOLE SODIUM |
摘要 |
A process for preparing esomeprazole sodium comprises the steps of providing a solution of esomeprazole sodium in a solvent constituted mainly of methanol or only of methanol; and carrying out precipitation or crystallisation of esomeprazole sodium from said solution. Esomeprazole sodium is preferably obtained from pure form of neutral racemate through chiral chromatography using methanol-based mobile phase, and a subsequent reaction with sodium source. Novel crystal and semicrystal forms of esomeprazole sodium can be provided repeatedly and in physically stable and highly pure form. |
申请公布号 |
WO2010003974(A3) |
申请公布日期 |
2010.07.01 |
申请号 |
WO2009EP58650 |
申请日期 |
2009.07.08 |
申请人 |
LEK PHARMACEUTICALS D.D.;MANDIC, DEJAN |
发明人 |
MANDIC, DEJAN |
分类号 |
C07D401/12;A61K31/4439 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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