<p>The present invention provides a method for separating desired interferon isoforms from undesired interferon isoforms that involves subjecting the isoforms to anion exchange column chromatography and a biphasic elution procedure. A strong elution solution is used in the first elution phase to facilitate elution of the desired isoform from the column and a weak elution solution is used in the second phase to suppress elution of the desired isoforms.</p>
申请公布号
WO2010075159(A1)
申请公布日期
2010.07.01
申请号
WO2009US68433
申请日期
2009.12.17
申请人
SCHERING CORPORATION;YANG, XIAOYU;VELLEKAMP, GARY, J.