发明名称 |
Dopamine and agonists and antagonists thereof for modulation of suppressive activity of CD4+CD25+ regulatory T cells |
摘要 |
Compositions and methods for modulation of the suppressive activity of CD4+CD25+regulatory T cells (Treg) on CD4+CD25− effector T cells (Teff) are provided. An agent selected from: (i) dopamine; (ii) a dopamine precursor; (iii) a D1-R agonist; (iv) a D2-R antagonist; (v) a combination of (i) and (ii); or (vi) a combination of (i), (ii) or (iii) with (iv), down-regulates the suppressive activity of Treg and is useful for treatment of cancer. An agent selected from (i) a dopamine D2-R agonist, (ii) a dopamine D1-R antagonist, and (iii) a combination of (i) and (ii), up-regulates the suppressive activity of Treg and is useful for treatment of an autoimmune disease or for controlling graft rejection in tissue/organ transplantation.
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申请公布号 |
US2010168085(A1) |
申请公布日期 |
2010.07.01 |
申请号 |
US20040557901 |
申请日期 |
2004.05.23 |
申请人 |
YESA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
EISENBACH-SCHWARTZ MICHAL;KIPNIS JONATHAN |
分类号 |
A61K31/5513;A61K;A61K31/135;A61K31/195;A61P35/04;A61P37/00;A61P37/06 |
主分类号 |
A61K31/5513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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