BICYCLIC PYRANONE DERIVATIVES AS NICOTINIC ACID RECEPTOR AGONISTS

摘要

The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complicaton, obesity, an obesity-related disorder or non-alcoholic fatty liver disease.Formula (I). Y is -C- when an optional and additional bond is present and Y is -CH- when an optional and additional bond is not present; Z is -O-, -NH- or -N(alkyl)- when the optional and additional bond between Y and Z Is absent, and Z Is -N- when the optional and additional bond between Y and Z is present; R1 is H1 halo or -CN; R2 is alkyl, alkenyl or -(alkyleneVcydoalkyl; t is 0 or 1; R3 is O when the optional and additional bond between Y and R3 is present, and R3 is alkyl. haloalkyl. -C(O)OR5. -alkylene-O-alkyt or -O-alkyl when the optional and additional bond between Y and R3 is absent: R4 is H, alkyl or aryl, wherein an aryl group can be unsubstituted or optionally substituted.