SUBSTITUTED PHENYLPIPERAZINYL ARALKYLALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND USES THEREOF

摘要

The substituted phenylpiperazinyl aralkylalcohol derivatives shown as the following formula (I), and the salts and hydrates thereof, in which C1 and C2 are chiral carbon atoms, the compound is one of six isomer of (1RS, 2SR), (1RS, 2RS), (1R,2S), (1S, 2S), (1R, 2R), or (1S, 2R), and R, R1, R2, R3 and Ar are defined as the definition in description, These derivatives are non-opioid analgesics, and they have good analgesic effects and lower toxicity and side effects. The pharmaceutical compositions containing such derivatives and the uses thereof.