The present invention relates to novel peptides that are selective corticotropin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity.
申请公布号
WO2010053990(A3)
申请公布日期
2010.07.01
申请号
WO2009US63276
申请日期
2009.11.04
申请人
JANSSEN PHARMACEUTICA NV;SWANSON, RONALD, V.;SHANKLEY, NIGEL, P.;MORENO, VERONICA;GENGO, PETER
发明人
SWANSON, RONALD, V.;SHANKLEY, NIGEL, P.;MORENO, VERONICA;GENGO, PETER