发明名称 |
CORYDALINE DERIVATIVES USEFUL FOR REDUCING LIPID LEVELS |
摘要 |
The present technology relates to compounds of Formulas (V) and (VI) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL- cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated potein kinase. |
申请公布号 |
WO2010075469(A1) |
申请公布日期 |
2010.07.01 |
申请号 |
WO2009US69331 |
申请日期 |
2009.12.22 |
申请人 |
CVI PHARMACEUTICALS LIMITED;LIU, HAIYAN;LI, GAOPING;WANG, JUNBO;LIU, JINGWEN |
发明人 |
LIU, HAIYAN;LI, GAOPING;WANG, JUNBO;LIU, JINGWEN |
分类号 |
C07D455/03;A61K31/4741;A61P3/06;C07D495/04 |
主分类号 |
C07D455/03 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|