发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE COMPOUNDS USING TRANSFER HYDROGENATION |
摘要 |
<p>A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drag substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate.</p> |
申请公布号 |
WO2010072798(A1) |
申请公布日期 |
2010.07.01 |
申请号 |
WO2009EP67821 |
申请日期 |
2009.12.23 |
申请人 |
NOVARTIS AG;MATHES, CHRISTIAN;FOULKES, MICHAEL;KESSELGRUBER, MARTIN |
发明人 |
MATHES, CHRISTIAN;FOULKES, MICHAEL;KESSELGRUBER, MARTIN |
分类号 |
C07B53/00;C07C37/00;C07C39/11;C07C213/08;C07C215/50;C07C269/06;C07C271/44;C07C309/64 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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