发明名称 |
IMMUNOGLOBULIN PURIFICATION |
摘要 |
<p>The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material.</p> |
申请公布号 |
WO2010072381(A1) |
申请公布日期 |
2010.07.01 |
申请号 |
WO2009EP09157 |
申请日期 |
2009.12.18 |
申请人 |
F. HOFFMANN-LA ROCHE AG;POMPIATI, MARC;SCHAUBMAR, ANDREAS |
发明人 |
POMPIATI, MARC;SCHAUBMAR, ANDREAS |
分类号 |
A61K39/395;C07K1/18;C07K16/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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