AZA-BICYCLO[2.2.1] HEPTENE DERIVATIVES, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING OSELTAMIVIR INTERMEDIATES USING THE SAME

摘要

The present invention relates to aza-bicyclo[2.2.1] heptene derivatives, a preparation method thereof, and a method for preparing Oseltamivir intermediates using the same. The aza-bicyclo[2.2.1] heptene derivatives of chemical formula 1 and prepared by the present invention: are valuable as raw materials for Oseltamivir; remarkably reduce processes for preparing the existing Oseltamivir; enable preparation of the Oseltamivir at low cost by using low-priced compounds widely used in industry instead of high-priced raw materials. Furthermore, the derivatives prevent generation of explosive materials during synthesis thereof, thereby enabling safe and economical preparation of the Oseltamivir.