NOVEL CHONDROITIN SULFATE HAVING DECREASED MOLECULAR WEIGHT AND USE THEREOF

摘要

It is intended to provide a chondroitin sulfate having a decreased molecular weight which is useful as an inhibitor of peritoneal disorder caused by long-term use of a peritoneal dialysis fluid containing glucose or a polysaccharide of glucose as an osmotic substance or is useful as an osmotic substance in a peritoneal dialysis fluid. The chondroitin sulfate having a decreased molecular weight of the invention as a resolution means is characterized in that it has a weight average molecular weight of from 1000 to 20000 and comprises a constituent disaccharide unit represented by the following structural formula in an amount of from 65% to 100% (molar ratio) of the total.-[4GlcAF1-3GalNAcF1]-] In the formula, GlcA represents a D-glucuronic acid residue; GalNAc represents a N-acetyl-D-galactosamine residue; β1-3 represents a β1-3 glycosidic linkage; β1-4 represents a β1-4 glycosidic linkage; and indicates that a group at the 6th position in the monosaccharide residue is sulfated.