发明名称 |
DNA VACCINES AGAINST TUMOR GROWTH AND METHODS OF USE THEREOF |
摘要 |
A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a DNA construct operably encoding a cancer-associated Inhibitor of Apoptosis-family protein and an immunoactive gene product, such as a cytokine or a ligand for a natural killer cell surface receptor, in a pharmaceutically acceptable carrier. A preferred cytokine is CCL21. Preferred ligands for a natural killer cell surface receptor include human MICA, human MICB, human ULBP1, human ULBP2, and human ULBP3. The cancer-associated Inhibitor of Apoptosis (IAP)-family protein is preferably a survivin protein or livin protein. Method of inhibiting tumor growth by administering the vaccine of the invention to a mammal is also described. |
申请公布号 |
EP1622648(B1) |
申请公布日期 |
2010.06.30 |
申请号 |
EP20040749425 |
申请日期 |
2004.03.24 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
XIANG, RONG;ZHOU, HE;REISFELD, RALPH A. |
分类号 |
A61K48/00;A61K39/00;C07H21/00;C12N1/20 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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