发明名称 |
Cytotoxin-based biological containment |
摘要 |
<p>Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the <Italic>E</Italic>. <Italic>coli</Italic> relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollulant degrading organisms or as biogical pest control organisms e.g. expressing <Italic>B. thuringiensis</Italic> crystalline proteins.</p> |
申请公布号 |
EP2180050(A3) |
申请公布日期 |
2010.06.30 |
申请号 |
EP20090168998 |
申请日期 |
1999.05.07 |
申请人 |
UNIVERSITE LIBRE DE BRUXELLES |
发明人 |
GERDES, KENN;GOTFREDSEN, MARIE;GROENLUND, HUGO;PETERSEN, KIM;KRISTOFFERSEN, PETER |
分类号 |
C12N15/00;C12N15/63;C12N15/68;C12N15/74 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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