发明名称 |
DUAL-ACTING ANTIHYPERTENSIVE AGENTS |
摘要 |
<p>The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.</p> |
申请公布号 |
EP2200975(A1) |
申请公布日期 |
2010.06.30 |
申请号 |
EP20080830513 |
申请日期 |
2008.09.05 |
申请人 |
THERAVANCE, INC. |
发明人 |
CHOI, SEOK-KI;FATHEREE, PAUL, R.;GENDRON, ROLAND;HUDSON, RYAN;MCKINNELL, ROBERT, MURRAY;SASIKUMAR, VIVEK |
分类号 |
C07C259/06;A61K31/195;A61K31/41;A61P9/04;A61P9/12;C07C323/60;C07D207/16;C07D257/04;C07D403/12 |
主分类号 |
C07C259/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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