<p>The present invention relates to a novel CKalpha-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKalpha-5 protein. CKalpha-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKalpha-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKalpha-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.</p>
申请公布号
EP1036164(B1)
申请公布日期
2010.06.30
申请号
EP19980958066
申请日期
1998.11.18
申请人
HUMAN GENOME SCIENCES, INC.
发明人
WEI, YING-FEI;NI, JIAN;LI, YI;ROSEN, CRAIG, A.;RUBEN, STEVEN, M.