RADIOACTIVE ARSENIC-CONTAINING COMPOUNDS AND THEIR USES IN THE TREATMENT OF TUMORS

摘要

THIS INVENTION PROVIDES A PROCESS FOR PRODUCING A RADIOACTIVE ARSENIC-CONTAINING COMPOUND,COMPRISING THE STEPS OF : (i) SUBJECTING AN ARSENIC-CONTAINING COMPOUND TO A NEUTRON IRRADIATION TREATMENT, SAID ARSENIC-CONTAINING COMPOUND BEING SELECTED FROM A GROUP CONSISTING OF AS₂O₃,AS₂S₃,AS₂S₂, AND A COMBINATION THEREOF, SUCH THAT THE ARSENIC ELEMENT CONTAINED IN THE ARSENIC-CONTAINING COMPOUND IS CONVERTED TO A RADIOACTIVE ARSENIC ISOTOPE; AND (ii) RECOVERING THE RESULTANT PRODUCT FROM STEP (i). THIS INVENTION ALSO PROVIDES A PHARMACEUTICAL COMPOSITION COMPRISING A THERAPEUTICALLY EFFECTIVE AMOUNT OF THE RADIOACTIVE ARSENIC-CONTAINING COMPOUND AND A PHARMACEUTICALLY ACCEPTABLE CARRIER. THE PHARMACEUTICAL COMPOSITION CAN BE USED IN THE TREATMENT OF TUMORS/CANCERS SUCH AS HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS.