发明名称 |
Process for the preparation of pleuromutilins |
摘要 |
A process for the preparation of 14-O-[(N-(3-methyl-2-amino-butyryl-piperidinyl)sulfanyl) acetyl]mutilins of formula
feasible for large-scale production of high purity products, and wherein the carbon atom at the piperidine ring attached to the sulphur atom is either in the (S)-configuration or in the (R)-configuration, and a new crystalline form of 14-O-[(N-3-methyl-2-(R)-amino-butyryl-piperidine-3(S)-yl)sulfanyl)acetyl]mutilin - hydrochloride. |
申请公布号 |
ZA200902159(B) |
申请公布日期 |
2010.06.30 |
申请号 |
ZA20090002159 |
申请日期 |
2007.10.03 |
申请人 |
NABRIVA THERAPEUTICS AG. |
发明人 |
MACHER, INGOLF;BERGER, ANDREAS;DECRISTOFORO, MARTIN |
分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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