Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenyl-imidazolone compounds as ²-secretase inhibitors
摘要
The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit beta-secretase (BACE) and treat beta-amyloid deposits and neurofibrillary tangles.
申请公布号
ZA200906542(B)
申请公布日期
2010.06.30
申请号
ZA20090006542
申请日期
2009.09.18
申请人
WYETH
发明人
MALAMAS, MICHAEL SOTIRIOS;ROBICHAUD, ALBERT JEAN;PORTE, ALEXANDER MICHAEL;SOLVIBILE, WILLIAM RONALD;MORRIS, KOI MICHELE;ANTANE, SCHUYLER ADAM;KIM, JI-IN;MCDEVITT, ROBERT EMMETT