发明名称 |
Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
摘要 |
Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.
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申请公布号 |
US7744888(B2) |
申请公布日期 |
2010.06.29 |
申请号 |
US20020051497 |
申请日期 |
2002.01.18 |
申请人 |
ABGENOMICS COOPERATIEF U.A. |
发明人 |
LIN RONG-HWA;WU CHUNG-HSIUN;HSU PEI-LING |
分类号 |
A61K39/395;G01N33/48;A61K45/00;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07K16/28;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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