发明名称 |
Methods and agents for preparing 18F-radiolabeled fluorinating agents |
摘要 |
The present invention is directed to a method for preparing an anhydrous 18F-radiolabeled fluorinating agent by a nucleophilic reaction of a hydrated 18F-radiolabeled fluoride ion source with an unsaturated carrier compound; treating the 18F-radiolabeled carrier compound to produce a non-aqueous mixture of the 18F-radiolabeled carrier compound in a solvent; and reacting the 18F-radiolabeled carrier compound with a nucleophilic composition in a nucleophilic reaction to produce an anhydrous 18F-radiolabeled fluorinating agent. The present invention is also directed to an anhydrous 18F-radiolabeled fluorinating agent comprising the formula [QnM]x+(18F−)x. Additionally, the present invention is directed to an 18F-radiolabeled fluorinated radiopharmaceutical or an 18F-radiolabeled fluorinated radiotracer prepared by reacting the anhydrous 18F-radiolabeled fluorinating agent with a drug intermediate. The present invention is further directed to methods for treating a disease or imaging a subject using an 18F-radiolabeled fluorinated radiopharmaceutical or an 18F-radiolabeled fluorinated radiotracer.
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申请公布号 |
US7744851(B2) |
申请公布日期 |
2010.06.29 |
申请号 |
US20070778349 |
申请日期 |
2007.07.16 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA |
发明人 |
DIMAGNO STEPHEN GREGORY;SUN HAORAN |
分类号 |
A61K51/04;A61K49/00;A61K101/02 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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