| 摘要 |
Compounds comprising an unbranched backbone carbon chain of 8-16C, optionally substituted at any position with 1-5 alkyl groups (1-6C) or with halo, = O, OR, SR, NR2, OOCR, NROCR, or N(OCR)2, wherein R is H, alkyl (1-6C), optionally substituted aryl (6-10C), arylalkyl (7-12C) wherein said aryl is optionally substituted, and wherein two R on the same substitutent may form a ring, or with phosphate or pyrophosphate or the alkyl (1-6C) esters thereof; and/or wherein a terminal carbon is optionally in the form of COOR -CONR2 or -COR wherein R is H, alkyl (1-6C) or arylalkyl (7-12C); and wherein said chain may optionally contain 1-4.pi.-bonds or the epoxides thereof are useful as N-type calcium channel inactivation blockers. Libraries of these compounds can also be used to identify antagonists for other targets.
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