发明名称 G CAP-STABILIZED OLIGONUCLEOTIDES
摘要 The invention relates to oligonucleotides of the formula 5'-(CAP)-(oligo)-(CAP)-3 where (Oligo) is a nucleotide sequence of from 10 to 40 nucleotides in length, and CAP is Gm, where m is an integer of from zero to ten, preferably of from two to six, particularly preferably of from three to five and very particularly preferably four, and where the two CAP's which are present in the molecule can be defined independently of each other and must be different in the case where m is zero at the 5' or 3' end and the end of the "Oligo" sequence is not formed by a guanine, to a process for their preparation, to pharmaceuticals con-taining the novel oligonucleotides, and to their use for preparing a pharmaceutical for treating diseases or for preparing a diagnostic agent.
申请公布号 CA2168409(C) 申请公布日期 2010.06.29
申请号 CA19962168409 申请日期 1996.01.30
申请人 HOECHST AKTIENGESELLSCHAFT 发明人 PEYMAN, ANUSCHIRWAN;UHLMANN, EUGEN
分类号 C07H21/00;C12N15/09;A61K31/70;A61K31/7088;A61K38/00;A61P31/12;A61P35/00;C07H21/04;C12N15/113 主分类号 C07H21/00
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