发明名称 |
Multi-arm cyclic or cubic siloxane-based formulations for drug delivery |
摘要 |
The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.
|
申请公布号 |
US7745547(B1) |
申请公布日期 |
2010.06.29 |
申请号 |
US20060500175 |
申请日期 |
2006.08.07 |
申请人 |
BECTON, DICKINSON AND COMPANY;RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NY |
发明人 |
AUERBACH ANDREW;CHAUHAN BHANU P. S.;CLARKE RICHARD P.;HAIDER M. ISHAQ;LATIF UMAR |
分类号 |
C08L73/00 |
主分类号 |
C08L73/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|